复方丹参气雾剂合用硝酸甘油治疗冠心病心绞痛的疗效

中国中西医结合急救杂志 2000年第2期第7卷 论著

作者：关中宪　张学全

关键词：心绞痛，冠心病；复方丹参气雾剂；硝酸甘油

　　摘　要：目的：评价复方丹参气雾剂合用硝酸甘油治疗冠心病心绞痛的疗效。方法：将90例冠心病心绞痛患者随机分为3组：A组30例给予复方丹参气雾剂；B组30例给予复方丹参气雾剂，另加硝酸甘油静滴；C组单用硝酸甘油静滴。观察治疗前后3组疗效(心电图和症状)，并观察A、B组血液流变学改变，B、C组硝酸甘油用量。结果： A组症状及心电图总有效率分别为76.7％和46.7％；C组症状及心电图总有效率分别为73 .3%和43.3％，2组比较差异无显著性(P均＞0.05)；B组症状及心电图总有效率分别为96.7％和60.0％，均优于上述2组(P均＜0.05)。A组、B组治疗前后血液流变学有显著改善，且B组与A组有显著差异(P＜0.05或P＜0.01)。B组硝酸甘油用量显著少于C组(P＜0.05)。结论：复方丹参气雾剂是治疗冠心病心绞痛的有效药物，与硝酸甘油合用可增强疗效，且能减少硝酸甘油用量，抑制其不良反应。

　　分类号：R541.4　文献标识码：A

　　文章编号：1008-9691(2000)02-0069-02

Curative effect of composite salvia miltiorrhiza bunge complex aerosol on ische mic angina pectoris

　GUAN Zhongxian　ZHANG Xuequan.

　　（Yanzhou People′s Hospital, Yanzhou 272000）

　　Abstract：Objective：To evaluate the curative effect of composite salvia miltiorrhiza bunge complex a erosol (SMBC) on ischemic angina pectoris.Methods：90 cases with ischemic angina pectoris were randomly divided into three groups,t he patients of group A were administered sMBC;the patients of group B were admin istered the mentioned SMBC and nitroglycerin;the patients of group C were admini stered nitroglycerin.The curative effect (ECG and symptom) of three groups was contrasted and observed before and after treatment;the alteration of hemorrheolo gy of group A and group B,and the dosage of nitroglycerin of group B and group C were observed.Results：The total effective rate of symptom(76.7％ vs.73.3%) and ECG(46.7％ vs.43.3％) in group a and group C were similiar (all P＞0.05),the curative effects(96.7％ and 60.0％,respectively) in group B significantly higher than group A and group C(all P＜0.05).The alteration of hemorrheology of g roup a significantly more than group B (P＜0.05 or P＜0.01).The do sage of nitroglycerin in group B was markedly lower than group C(P＜0.05 ).Conclusions：SMBC is an effective drug for ischemic angina pectoris.Combine with SMBC and ni troglycerin can enhance curative effect and decrease the dosage of nitroglyceri n and can inhibit the deleterious effe