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类胰升血糖素肽-1免疫细胞在胎儿胃肠道中的分布

类胰升血糖素肽-1免疫细胞在胎儿胃肠道中的分布

解剖科学进展 2000年第4期第6卷 原著

作者:李艳君 王俊波 扈清云 姜吉文

单位:佳木斯大学医学院解剖教研室 佳木斯 154002

关键词:类胰升血糖素肽-1;胃肠道;免疫组织化学;胎儿

  摘要 为了研究类胰升血糖素肽-1(Glucagon-like Peptide-1,GLP-1)在胎儿的胃肠道中的分布情况,应用免疫组织化学ABC法,对5例约23周左右胎儿胃肠道内GLP-1免疫细胞进行定位研究。结果表明,胎儿胃肠道中GLP-1免疫细胞密度最大的是直肠,其次是结肠和回肠。GLP-1免疫细胞主要分布在肠道远端。

Localization of Glucagon-like peptide-1 Immunoreactive Cells in the Gastrointestinal Tract of Fetus

Li Yanjun, Wang Junbo, Hu Qingyun

  (Department of Anatomy, Jiamusi Medical College, Jiamusi 154002)

  The localization of GLP-1 in the gastrointestinal tract of fetus were studied by immunohistochemical ABC method. The results indicated that the hightest GLP-1 immunoreactive cells desity occurred in the rectus, then in the colon descendens and ileum. GLP-1 immunoreactive cells predominantly located in the distal intestinal tract.

  Key words glucagon-like peptide-1; gastrointestinal tract; immunohistochemistry; fetus

参考文献

  1,Nauck MA, Bartels E, Orskov, et al. Additive insulinitropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol metab, 1993, 76:91

  2,Eissele R, Goke R, Willemer S, et al. Glucagonlike peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest, 1992,22:283

  3,Goke, Fehmann HC. Glucagon-like peptide-1(7-36) amide is a new incretin. Eur J Clin Invest, 1991,21:135

  4,Orkov C, Rabenhoj L, Wettergren A, et al. Tissue and plasma concentrations of amidated and glycineextended glucagon-like peptide-1 in humans. Diabetes, 1994,43:535

  5,Nozaki M, Miyata K, Oota Y, et al. Colocalization of glucagon-like peptide and glucagon immunoreactivities in pancreatic islets and intestine of salmonids. Tissue res, 1988,253:371

  6,Todd JF, Wilding JP, Edwards CM, et al. Glucagonlike peptide-1(GLP-1). a trial of treatment in noninsulin-dependent diabetes mellitus. Eur J Clin Invest, 1997, 27:533


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